Author: Carolina Pure

The hemp and cannabis industries come with a whole host of new terminology that can get confusing even for those of us in the industry.  One term we are seeing questions about is “phytocannabinoid”, so let’s explore that one in this blog post.

While many people are now familiar with the term “cannabinoid” (the active ingredient in hemp and marijuana products: CBD, THC, etc), “phytocannabinoid” is a bit less well-known.  The difference between the two is pretty small and not all that complicated.

Our Endocannabinoid System

Our bodies contain an endocannabinoid system (much more detail here) that creates its own cannabinoids and it plays an important role in the release of neurotransmitters like serotonin and dopamine for critical brain functions.  The same system also helps guide our immune system which includes our response to inflammation and pain.  This endocannabinoid system provides many opportunities for cannabinoids to bind to receptors, which, when activated, help to maintain a healthy body.

Cannabinoids made by our bodies (and mammals in general) are referred to as endocannabinoids while cannabinoids made by plants are known as phytocannabinoids.  That’s it.  Phytocannabinoids are just cannabinoids that our body doesn’t make.  It was thought for a while that only hemp and cannabis (I use the terms “marijuana” and “cannabis” interchangeably in this post) plants contained phytocannabinoids, which are found concentrated in the trichomes of the plants.  These are the little crystals found on the surface of the leaves and the flowers (“buds”) of a hemp or marijuana plant.  However, cannabinoids have been found more recently in black pepper, broccoli, carrots, and other plants.

How Many Phytocannabinoids Are there?

A lot.  While the prominent cannabinoids–THC, CBD, CBG, CBN–are the ones featured in most of the current hemp products on the market, there are one hundred or more total cannabinoids and many more terpenes and flavonoids on top of that.  I will discuss each of those in greater detail in future blog posts, but the short version is that these are also molecules found in hemp and marijuana plants that bind to our cells and affect the way we metabolize various cannabinoids.  I have written about my experience with CBD and what a profound impact it had on my daily life when it relieved my sciatica and osteoarthritis pain almost entirely.  But I’m also of the opinion that we are just getting started learning about the amazing properties of these plants as research has barely begin in the other 90+ cannabinoids about which little is known. And then there are the flavonoids and terpenes.  If I sound like a zealot, it’s because I am.  But with good reason!

The “Entourage Effect”

While my initial experience with CBD and the resulting pain relief that followed came from just four day’s use of CBD isolate–a form of CBD that is 99.9% pure CBD with no other parts of the hemp plant–mixed with water, I have learned since then about the “entourage effect”.  An Israeli doctor, Dr. Raphael Mechoulam, came up with this phrase to describe the result of the various components of the hemp (or marijuana) plant acting together to deliver benefits to the user that are greater than the sum of the individual cannabinoids, flavonoids, and terpenes.  

Dr. Mechoulam’s research showed that cannabis/hemp molecules team up to provide synergies that enhance the beneficial effects of the plant.  While I often recount my initial experience with CBD isolate and think it’s a great active ingredient in a number of products for a few different reasons, there is no doubt that there are a great many additional benefits to be found in the other parts of the plant.  While there is no definitive proof (yet!) to substantiate Dr. Mechoulam’s entourage effect hypothesis, count me among those who will be zero percent surprised when that proof does emerge after more research is conducted.

Cannabinoids are the compounds that bind to receptors in our body’s endocannabinoid system and play a key role in maintaining our overall health in a variety of ways.  Phytocannabinoids are cannabinoids made by plants and endocannabinoids are made by our bodies (and in other mammals).  The entourage effect is a term that refers to the synergistic effect of different cannabinoids, terpenes and flavonoids (both are good-for-you molecules also found in plants) all working together to accentuate the beneficial properties of hemp and cannabis plants.

I would like to introduce you to the person who convinced me to try CBD and therefore to the formation of Carolina Pure: guitarist extraordinaire and all-around super cool person, Justin Cody Fox.  I met Justin 19 years ago when I first moved to Wilmington, NC.  My brother and I both play guitar and we were heading out to a new bar when we heard what we thought was a VERY loud Jimi Hendrix bootleg CD (under 35?  look it up..) coming from across the street.  We went over to see what was up. As we watched Justin, bassist Dave Morse, and Justin’s cousin, Jeremy Summers on the drums, tear through their first set of amazing blues-based rock, we looked at each other and one of us said something like “are there bands like this just hanging out in Wilmington all over”?  Answer: no.  There is only one Justin Fox, and I’m pleased to call him my friend.  Check him out live if you’re in the area or online if you don’t.  I promise you won’t regret it.

Justin and I have been talking about collaborating on hemp stuff for years.  Well, Justin, we’re finally doing it!  

I would also like to introduce you to another local non-profit founded and run by my friend, person extraordinaire, Peter Maguire.  Peter has a doctorate in history and taught for 20 years at Columbia University, is an accomplished writer with an awesome substack and too much material to his credit to list here, was a war correspondent covering the Khmer Rouge in Cambodia, and has been a military contractor and is maybe the only person who hangs with both some of the world’s best known big wave riders as well as the world’s best mixed martial artists–Peter counts Gracie family patriarch, Rickson Gracie, as both a friend and Jiu Jitsu mentor.  Don’t mess with either of them.  DO read “Breathe”, Rickson’s biography that Peter co-authored.  
I could go on, but the point is that Peter is a kind of real-life Indiana Jones.  I mean, his kids (Hey Joe and Sea!)  are more accomplished than half the adults I know.  His foundation, Fainting Robin is also super cool.  For the most part, it focuses on recognizing and supporting underpaid and under-appreciated college professors with a little-to-no chance at tenure.  That alone is pretty cool, but it gets better. Fainting Robin also has a “special activities” component, that does all kinds of fascinating stuff.  Most recently, it was instrumental in bringing a Cambodian killer to justice and supported Peter’s friend, “Nug”, a former operator who has been killing time in Ukraine, rescuing Americans trapped in the war-torn country.  If you stop by Peter’s house, you’re as likely to find a teams guy training as you are the mailman.  I told you it was super cool.